Nitrosphere is more secure. Traditional WAN accelerators can encrypt traffic between locations, but in order to implement encryption, they require that you provide the encryption keys for applications you want to accelerate. This means that the appliance first decrypts the data, then operates on it, then re-encrypts it. This is not real end-to-end encryption.
Hardware accelerators also increase the attack surface for hackers by caching sensitive data to disks on the device, meaning that if the appliance is breached, so is your enterprise. Nitrosphere is the only true end-to-end encryption and acceleration provider.
Nitrosphere enables you to implement applications with modern architectures while enabling you to make decisions based on what your end users need without the limitation of worrying about performance or security changes at the endpoint.