Use SSMS to run a representative query from your application both with and without Nitro.
Measure application load time and common processes/queries.
Longer term testing is often recommended for many use cases. The HyperCache feature learns and improves over time and helps dramatically accelerate chatty applications.
Measure transactional replication latency before and after (ms)
Below are tests running DML and Queries. They are representative of a server-client benefit.